Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes
نویسندگان
چکیده
منابع مشابه
Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes.
Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120-360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The p...
متن کاملMechanisms controlling drug release from coated pellets.
Since the use of PEG-coated pellets for the first oral sustainedrelease formulation in 1952, coated pellets have been used extensively to control the drug release kinetics. The term “pellet” has been used interchangeably with other terms, such as bead, sphere, granule, and particle. A large number of drug products have been available to patients. Despite extensive use of the coated pellets, the...
متن کاملMechanism of Release from Pellets Coated with an Ethylcellulose-based Film
Studies were conducted to determine the mechanism of drug release from pellets coated with an ethylcellulose-based pseudolatex widely accepted for use as a sustained release coating for pharmaceuticals. Possible mechanisms for release include solution/diffusion through the continuous polymer phase and/or plasticizer channels, diffusion through aqueous pores and osmotically driven release throug...
متن کاملStudy of the Recrystallization in Coated Pellets
Coated multiparticulate systems are increasingly popular on the market. Their manufacture in a fluid bed often requires polymer binders. Polymers have been widely studied as inhibitors of crystallization [1]. Migration of drugs into the coating layer has also been described [2] but the influence of the coating polymers on the crystallization of the drug is yet to be studied in more depth. In ou...
متن کاملIn vitro Release Kinetics Study of Diclofenac Sodium from Acrylic Polymer Coated Pellets
The aim of the present study is to investigate the effect of Ammonio Methacrylate Copolymer Type B (Eudragit RS 30 D) on the release kinetics study of diclofenac sodium form coated pellets. The effect of the incorporation of xanthan gum into the coating formulation was also the goal of this study. Eudragit RS 30 D and xanthan gum was added into the formulation at 5:1 ratio. Different percent of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2016
ISSN: 1846-9558
DOI: 10.1515/acph-2016-0017